InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.43192

Summary

InnateDB Gene

IDBG-633884.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.43192

Gene Name

HUS1 checkpoint protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013226

Encoded Proteins

IDBP-685667

HUS1 checkpoint protein

IDBP-685669

HUS1 checkpoint protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136273:
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:75146925-75159359

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017599	ENSBTAP00000017599
ENSBTAT00000033617	ENSBTAP00000033527

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000724	double-strand break repair via homologous recombination
GO:0001932	regulation of protein phosphorylation
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007093	mitotic cell cycle checkpoint
GO:0008156	negative regulation of DNA replication
GO:0009411	response to UV
GO:0009790	embryo development
GO:0071479	cellular response to ionizing radiation