Homo sapiens Gene: HUS1
Summary
InnateDB Gene IDBG-16063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HUS1
Gene Name HUS1 checkpoint homolog (S. pombe)
Synonyms hHUS1;
Species Homo sapiens
Ensembl Gene ENSG00000136273
Encoded Proteins
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
HUS1 checkpoint homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:47695730-47979581
Strand Reverse strand
Band p12.3
Transcripts
ENST00000258774 ENSP00000258774
ENST00000436444 ENSP00000403844
ENST00000458191 ENSP00000400727
ENST00000432325 ENSP00000416588
ENST00000442024 ENSP00000404348
ENST00000432627 ENSP00000404855
ENST00000433977 ENSP00000405175
ENST00000446009 ENSP00000398806
ENST00000468868
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 36 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000724 double-strand break repair via homologous recombination
GO:0001932 regulation of protein phosphorylation
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0008156 negative regulation of DNA replication
GO:0009411 response to UV
GO:0009790 embryo development
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030896 checkpoint clamp complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G2/M Checkpoints pathway
Cell Cycle pathway
Activation of ATR in response to replication stress pathway
Cell Cycle Checkpoints pathway
KEGG
INOH
PID BIOCARTA
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
PID NCI
Fanconi anemia pathway
ATR signaling pathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.152983
RefSeq NM_004507
HUGO
OMIM
CCDS CCDS34635
HPRD 04787
IMGT
EMBL
GenPept
RNA Seq Atlas