InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.54076

Summary

InnateDB Gene

IDBG-634507.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.54076

Gene Name

sodium/potassium-transporting ATPase subunit alpha-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001246

Encoded Proteins

IDBP-686304

sodium/potassium-transporting ATPase subunit alpha-1 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163399:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:27002873-27025641

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001646

ENSBTAP00000001646

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0008217	regulation of blood pressure
GO:0015672	monovalent inorganic cation transport
GO:0016311	dephosphorylation
GO:0031947	negative regulation of glucocorticoid biosynthetic process
GO:0042493	response to drug
GO:0045822	negative regulation of heart contraction
GO:0045823	positive regulation of heart contraction
GO:0045989	positive regulation of striated muscle contraction
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome