InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DLG4

Summary

InnateDB Gene

IDBG-634574.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG4

Gene Name

disks large homolog 4

Synonyms

LLGL1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002564

Encoded Proteins

IDBP-686352

discs, large homolog 4 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132535:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:27543283-27565410

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003326

ENSBTAP00000003326

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 346 interaction(s) predicted by orthology.

Predicted by orthology
Total	346 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0016188	synaptic vesicle maturation
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0035641	locomotory exploration behavior
GO:0045184	establishment of protein localization
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050885	neuromuscular process controlling balance
GO:0071625	vocalization behavior
GO:2000821	regulation of grooming behavior

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030863	cortical cytoskeleton
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043197	dendritic spine
GO:0044224	juxtaparanode region of axon
GO:0044300	cerebellar mossy fiber
GO:0044306	neuron projection terminus
GO:0044309	neuron spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000132535

View Gene Order

ENSMUSG00000020886

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20546

Ras activation uopn Ca2+ infux through NMDA receptor pathway

REACT_20568

CREB phosphorylation through the activation of Ras pathway

REACT_20642

CREB phosphorylation through the activation of CaMKII pathway

REACT_20594

Unblocking of NMDA receptor, glutamate binding and activation pathway

REACT_18307

Trafficking of AMPA receptors pathway

REACT_22329

NrCAM interactions pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_13685

Neuronal System pathway

REACT_21322

Ionotropic activity of Kainate Receptors pathway

REACT_18266

Axon guidance pathway

REACT_20593

Post NMDA receptor activation events pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_20563

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21346

Activation of Ca-permeable Kainate Receptor pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_18347

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway

REACT_198684

Ionotropic activity of Kainate Receptors pathway

REACT_198685

Activation of Kainate Receptors upon glutamate binding pathway

REACT_203664

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_198694

Activation of Ca-permeable Kainate Receptor pathway

REACT_198244

Ras activation uopn Ca2+ infux through NMDA receptor pathway

REACT_198246

CREB phosphorylation through the activation of Ras pathway

REACT_198248

CREB phosphorylation through the activation of CaMKII pathway

REACT_218233

Post NMDA receptor activation events pathway

REACT_261444

Axon guidance pathway

REACT_230679

NrCAM interactions pathway

REACT_219680

L1CAM interactions pathway

REACT_259290

Neuronal System pathway

REACT_188576

Developmental Biology pathway

REACT_258217

Unblocking of NMDA receptor, glutamate binding and activation pathway

REACT_233318

Transmission across Chemical Synapses pathway

REACT_214376

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

KEGG

hsa05016

Huntington's disease pathway

mmu05016

Huntington's disease pathway

INOH

PID NCI

erbb4_pathway

ErbB4 signaling events

Cross-References

SwissProt

TrEMBL

F1MM66

UniProt Splice Variant

Entrez Gene

100137840

UniGene

Bt.44381

RefSeq

NM_001191307 XM_005220169 XM_005220170 XM_005220171 XM_005220172

HUGO

HGNC:2903

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02048760

GenPept

RNA Seq Atlas

100137840