InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SENP2

Summary

InnateDB Gene

IDBG-634770.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SENP2

Gene Name

sentrin-specific protease 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001749

Encoded Proteins

IDBP-686577

SUMO1/sentrin/SMT3 specific peptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22028379

[Homo sapiens] SENP2 acts as a negative regulator of virus-triggered IFN-beta induction by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. (Demonstrated in mice)

PMID 22028379

[Mus musculus] Senp2 acts as a negative regulator of virus-triggered IFN-beta induction by deSUMOylating Irf3 and conditioning it for ubiquitination and degradation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163904:
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:82176394-82210749

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002296

ENSBTAP00000002296

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016929	SUMO-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0007507	heart development
GO:0016926	protein desumoylation
GO:0032875	regulation of DNA endoreduplication
GO:0035562	negative regulation of chromatin binding
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060707	trophoblast giant cell differentiation
GO:0060711	labyrinthine layer development
GO:0060712	spongiotrophoblast layer development
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:2000045	regulation of G1/S transition of mitotic cell cycle