Bos taurus Gene: BT.28504
Summary
InnateDB Gene IDBG-634951.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.28504
Gene Name unconventional prefoldin RPB5 interactor
Synonyms C18H19orf2; RMP;
Species Bos taurus
Ensembl Gene ENSBTAG00000007559
Encoded Proteins
unconventional prefoldin RPB5 interactor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105176:
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:40683382-40745558
Strand Forward strand
Band
Transcripts
ENSBTAT00000009950 ENSBTAP00000009950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001558 regulation of cell growth
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006457 protein folding
GO:0009615 response to virus
GO:0010923 negative regulation of phosphatase activity
GO:0071363 cellular response to growth factor stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005737 cytoplasm
GO:0016272 prefoldin complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F1MTD6
UniProt Splice Variant
Entrez Gene 515119
UniGene Bt.28504
RefSeq NM_001035305
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046782
GenPept
RNA Seq Atlas 515119