Bos taurus Gene: ADORA3
Summary
InnateDB Gene IDBG-635062.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA3
Gene Name adenosine receptor A3 isoform 2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000039738
Encoded Proteins
adenosine receptor A3 isoform 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121933:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:31900284-31986507
Strand Forward strand
Band
Transcripts
ENSBTAT00000049273 ENSBTAP00000046189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0002553 histamine secretion by mast cell
GO:0002687 positive regulation of leukocyte migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0043306 positive regulation of mast cell degranulation
GO:0050729 positive regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0042629 mast cell granule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (i) signalling events pathway
Adenosine P1 receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Nucleotide-like (purinergic) receptors pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
INOH
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001079645
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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