InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adora3

Summary

InnateDB Gene

IDBG-183869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adora3

Gene Name

adenosine A3 receptor

Synonyms

1700001D09Rik; 4930578J19Rik; A3AR; A3R; AA3R; ARA3; Gpcr2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074344

Encoded Proteins

IDBP-183871

adenosine A3 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121933:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:105870907-105924036

Strand

Forward strand

Band

F2.2

Transcripts

ENSMUST00000010279

ENSMUSP00000010279

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0002553	histamine secretion by mast cell
GO:0002687	positive regulation of leukocyte migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0043306	positive regulation of mast cell degranulation
GO:0050729	positive regulation of inflammatory response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070257	positive regulation of mucus secretion