Version 5.4
| Bos taurus Gene: MFN1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-636012.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | MFN1 | ||||||||
| Gene Name | mitofusin-1 | ||||||||
| Synonyms | MFN2 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000010485 | ||||||||
| Encoded Proteins |
mitofusin 1
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
[Mus musculus] Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171109:
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 1:88263740-88387147 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MPL1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 515180 | ||||||||
| UniGene | Bt.39430 | ||||||||
| RefSeq | NM_001206508 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02001961 DAAA02001962 DAAA02001963 DAAA02001964 DAAA02001965 DAAA02001966 DAAA02001967 DAAA02001968 DAAA02001969 DAAA02001970 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 515180 | ||||||||