InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mfn1

Summary

InnateDB Gene

IDBG-136722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mfn1

Gene Name

mitofusin 1

Synonyms

2310002F04Rik; 6330416C07Rik; D3Ertd265e; HR2; mKIAA4032

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027668

Encoded Proteins

IDBP-136724

mitofusin 1

IDBP-401601

mitofusin 1

IDBP-536470

mitofusin 1

IDBP-536956

mitofusin 1

IDBP-533527

mitofusin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21285412

Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.

InnateDB Annotation from Orthologs

Summary

PMID 21285412

[Homo sapiens] MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171109:
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:32529465-32579239

Strand

Forward strand

Band

Transcripts

ENSMUST00000091257	ENSMUSP00000088801
ENSMUST00000118286	ENSMUSP00000113251
ENSMUST00000125182
ENSMUST00000147350	ENSMUSP00000116380
ENSMUST00000137565	ENSMUSP00000117411
ENSMUST00000140328
ENSMUST00000151320	ENSMUSP00000120960

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007275	multicellular organismal development
GO:0008053	mitochondrial fusion
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171109

View Gene Order

ENSBTAG00000010485

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q811U4

TrEMBL

D3Z4L5 D3Z5P8 F6XRI9

UniProt Splice Variant

Entrez Gene

67414

UniGene

Mm.290414

RefSeq

NM_024200 XM_006535525

OMIM

CCDS

CCDS17296

HPRD

IMGT

MGI ID

MGI:1914664

MGI Symbol

Mfn1

EMBL

AC130281 AK009490 AK018181 AK141611 AY174062 BC002133 BC047050 BC056641

GenPept

AAH02133 AAH47050 AAH56641 AAO34660 BAB31111 BAC25260 BAE24764

RNA Seq Atlas

67414