|Mus musculus Gene: Mfn1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||mitofusin 1|
|Synonyms||2310002F04Rik; 6330416C07Rik; D3Ertd265e; HR2; mKIAA4032;|
|Useful resources||Stemformatics EHFPI ImmGen|
Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
|InnateDB Annotation from Orthologs|
[Homo sapiens] MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171109:
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 3:32529465-32579239|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
Factors involved in megakaryocyte development and platelet production pathway
|UniProt Splice Variant|
|RNA Seq Atlas|