Mus musculus Gene: Mfn1
Summary
InnateDB Gene IDBG-136722.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfn1
Gene Name mitofusin 1
Synonyms 2310002F04Rik; 6330416C07Rik; D3Ertd265e; HR2; mKIAA4032;
Species Mus musculus
Ensembl Gene ENSMUSG00000027668
Encoded Proteins
mitofusin 1
mitofusin 1
mitofusin 1
mitofusin 1
mitofusin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171109:
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:32529465-32579239
Strand Forward strand
Band A3
Transcripts
ENSMUST00000091257 ENSMUSP00000088801
ENSMUST00000118286 ENSMUSP00000113251
ENSMUST00000125182
ENSMUST00000147350 ENSMUSP00000116380
ENSMUST00000137565 ENSMUSP00000117411
ENSMUST00000140328
ENSMUST00000151320 ENSMUSP00000120960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007275 multicellular organismal development
GO:0008053 mitochondrial fusion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290414
RefSeq NM_024200 XM_006535525
OMIM
CCDS CCDS17296
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas