Version 5.4
Homo sapiens Gene: MFN1
Summary
InnateDB Gene IDBG-66114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFN1
Gene Name mitofusin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171109
Encoded Proteins
IDBP-66116
mitofusin 1
IDBP-66120
mitofusin 1
IDBP-483530
mitofusin 1
IDBP-479362
mitofusin 1
IDBP-475304
mitofusin 1
IDBP-474859
mitofusin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21285412
MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
InnateDB Annotation from Orthologs
Summary
PMID 21285412
[Mus musculus] Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
Entrez Gene
Summary The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:179347692-179394931
Strand Forward strand
Band q26.33
Transcripts
ENST00000263969 ENSP00000263969
ENST00000357390 ENSP00000349963
ENST00000471841 ENSP00000420617
ENST00000467174 ENSP00000419134
ENST00000489329 ENSP00000420148
ENST00000474903 ENSP00000419926
ENST00000466287
ENST00000482661
ENST00000480636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0008053 mitochondrial fusion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027668
View Gene Order
ENSBTAG00000010485
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478383 Hs.668390 Hs.708940
RefSeq NM_033540 XM_005247595 XM_005247596
HUGO
OMIM
CCDS CCDS3228
HPRD 16344
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca