|Homo sapiens Gene: MFN1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||mitofusin 1|
|Useful resources||Stemformatics EHFPI ImmGen|
MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
|InnateDB Annotation from Orthologs|
[Mus musculus] Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 3:179347692-179394931|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Factors involved in megakaryocyte development and platelet production pathway
|UniProt Splice Variant|
|UniGene||Hs.478383 Hs.668390 Hs.708940|
|RefSeq||NM_033540 XM_005247595 XM_005247596|
|RNA Seq Atlas|