InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.66173

Summary

InnateDB Gene

IDBG-636329.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.66173

Gene Name

dihydropyrimidine dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031358

Encoded Proteins

IDBP-688255

dihydropyrimidine dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188641:
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:45563732-46487165

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007139

ENSBTAP00000007139

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0017150	tRNA dihydrouridine synthase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0006145	purine nucleobase catabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006210	thymine catabolic process
GO:0006212	uracil catabolic process
GO:0006214	thymidine catabolic process
GO:0006222	UMP biosynthetic process
GO:0008033	tRNA processing
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000188641

View Gene Order

ENSMUSG00000033308

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1023

Pyrimidine catabolism pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_957

Pyrimidine metabolism pathway

REACT_111217

Metabolism pathway

REACT_236186

Pyrimidine metabolism pathway

REACT_188937

Metabolism pathway

REACT_241108

Pyrimidine catabolism pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00770

Pantothenate and CoA biosynthesis pathway

hsa00410

beta-Alanine metabolism pathway

hsa00983

Drug metabolism pathway

mmu00410

beta-Alanine metabolism pathway

mmu00240

Pyrimidine metabolism pathway

mmu00770

Pantothenate and CoA biosynthesis pathway

mmu00983

Drug metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

F1N549

UniProt Splice Variant

Entrez Gene

281124

UniGene

Bt.2424

RefSeq

NM_174041

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02007797 DAAA02007798 DAAA02007799 DAAA02007800 DAAA02007801 DAAA02007802 DAAA02007803 DAAA02007804 DAAA02007805 DAAA02007806 DAAA02007807 DAAA02007808 DAAA02007809

GenPept

RNA Seq Atlas

281124