Homo sapiens Gene: DPYD
Summary
InnateDB Gene IDBG-100417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPYD
Gene Name dihydropyrimidine dehydrogenase
Synonyms DHP; DHPDHASE; DPD;
Species Homo sapiens
Ensembl Gene ENSG00000188641
Encoded Proteins
dihydropyrimidine dehydrogenase
dihydropyrimidine dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:97077743-97921049
Strand Reverse strand
Band p21.3
Transcripts
ENST00000370192 ENSP00000359211
ENST00000306031 ENSP00000307107
ENST00000474241
ENST00000460019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004152 dihydroorotate dehydrogenase activity
GO:0004158 dihydroorotate oxidase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017150 tRNA dihydrouridine synthase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006145 purine nucleobase catabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0006210 thymine catabolic process
GO:0006212 uracil catabolic process
GO:0006214 thymidine catabolic process
GO:0006222 UMP biosynthetic process
GO:0008033 tRNA processing
GO:0019483 beta-alanine biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyrimidine catabolism pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
beta-Alanine metabolism pathway
Pantothenate and CoA biosynthesis pathway
Drug metabolism pathway
INOH
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.335034 Hs.613866
RefSeq NM_000110 NM_001160301
HUGO
OMIM
CCDS CCDS30777 CCDS53346
HPRD 02036
IMGT
EMBL
GenPept
RNA Seq Atlas