InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DPYD

Summary

InnateDB Gene

IDBG-100417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYD

Gene Name

dihydropyrimidine dehydrogenase

Synonyms

DHP; DHPDHASE; DPD

Species

Homo sapiens

Ensembl Gene

ENSG00000188641

Encoded Proteins

IDBP-100419

dihydropyrimidine dehydrogenase

IDBP-100423

dihydropyrimidine dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:97077743-97921049

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000370192	ENSP00000359211
ENST00000306031	ENSP00000307107
ENST00000474241
ENST00000460019

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017150	tRNA dihydrouridine synthase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006145	purine nucleobase catabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006210	thymine catabolic process
GO:0006212	uracil catabolic process
GO:0006214	thymidine catabolic process
GO:0006222	UMP biosynthetic process
GO:0008033	tRNA processing
GO:0019483	beta-alanine biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033308

View Gene Order

ENSBTAG00000031358

Not yet available

Pathways

NETPATH

REACTOME

REACT_1023

Pyrimidine catabolism pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_957

Pyrimidine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00770

Pantothenate and CoA biosynthesis pathway

hsa00410

beta-Alanine metabolism pathway

hsa00983

Drug metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

Q12882

TrEMBL

UniProt Splice Variant

Entrez Gene

1806

UniGene

Hs.335034 Hs.613866

RefSeq

NM_000110 NM_001160301

HUGO

HGNC:3012

OMIM

612779

CCDS

CCDS30777 CCDS53346

HPRD

IMGT

EMBL

AB003063 AC091608 AC093576 AC099787 AC114878 AC138135 AK291217 AL356457 BC008379 BC064027 BC108742 BC131777 BC131778 BT006740 BX908805 CH471097 U09178 U20938 U57655 X95670

GenPept

AAA57474 AAB07049 AAB51366 AAH08379 AAH64027 AAI08743 AAI31778 AAI31779 AAP35386 BAA89789 BAF83906 CAA64973 CAH70570 CAI15125 EAW73002

RNA Seq Atlas

1806