Version 5.4
Bos taurus Gene: CREM
Summary
InnateDB Gene IDBG-637209.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREM
Gene Name cAMP-responsive element modulator
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016060
Encoded Proteins
IDBP-689211
cAMP-responsive element modulator
IDBP-689213
cAMP-responsive element modulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095794:
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:18496784-18563503
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021381 ENSBTAP00000021381
ENSBTAT00000055517 ENSBTAP00000050114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006687 glycosphingolipid metabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000095794
View Gene Order
ENSMUSG00000063889
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q1LZH5
TrEMBL
UniProt Splice Variant
Entrez Gene 540605
UniGene Bt.48141
RefSeq NM_001034710 XM_005214246 XM_005214247 XM_005214253
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102677 BC115995
GenPept AAI02678 AAI15996
RNA Seq Atlas 540605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca