Version 5.4
Bos taurus Gene: CUL2
Summary
InnateDB Gene IDBG-637219.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUL2
Gene Name cullin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007133
Encoded Proteins
IDBP-689230
cullin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108094:
Gene Information
Type Protein coding
Genomic Location Chromosome 13:18592918-18664294
Strand Forward strand
Band
Transcripts
ENSBTAT00000055001 ENSBTAP00000051032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 360 interaction(s) predicted by orthology.
Predicted by orthology
Total 360 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0030163 protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108094
View Gene Order
ENSMUSG00000024231
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_6900
Immune System pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_188957
Cellular responses to stress pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_230745
Immune System pathway
REACT_199108
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05200
Pathways in cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt
TrEMBL Q08DE9
UniProt Splice Variant
Entrez Gene 535219
UniGene
RefSeq NM_001076909 XM_005214224 XM_005214225 XM_005214226 XM_005214227
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123787 BC150023 DAAA02035372
GenPept AAI23788 AAI50024
RNA Seq Atlas 535219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca