InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NDE1

Summary

InnateDB Gene

IDBG-637277.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDE1

Gene Name

nuclear distribution protein nudE homolog 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015986

Encoded Proteins

IDBP-689277

nuclear distribution protein nudE homolog 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072864:
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:14189695-14237237

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021265

ENSBTAP00000021265

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0042802	identical protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0001764	neuron migration
GO:0007020	microtubule nucleation
GO:0007405	neuroblast proliferation
GO:0021987	cerebral cortex development
GO:0030900	forebrain development
GO:0031023	microtubule organizing center organization
GO:0047496	vesicle transport along microtubule
GO:0051298	centrosome duplication
GO:0051303	establishment of chromosome localization