Bos taurus Gene: NDE1
Summary
InnateDB Gene IDBG-637277.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDE1
Gene Name nuclear distribution protein nudE homolog 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015986
Encoded Proteins
nuclear distribution protein nudE homolog 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072864:
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:14189695-14237237
Strand Forward strand
Band
Transcripts
ENSBTAT00000021265 ENSBTAP00000021265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0001764 neuron migration
GO:0007020 microtubule nucleation
GO:0007405 neuroblast proliferation
GO:0021987 cerebral cortex development
GO:0030900 forebrain development
GO:0031023 microtubule organizing center organization
GO:0047496 vesicle transport along microtubule
GO:0051298 centrosome duplication
GO:0051303 establishment of chromosome localization
Cellular Component
GO:0000776 kinetochore
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0016020 membrane
GO:0031616 spindle pole centrosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Mitotic Metaphase and Anaphase pathway
Recruitment of mitotic centrosome proteins and complexes pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Separation of Sister Chromatids pathway
Resolution of Sister Chromatid Cohesion pathway
Loss of Nlp from mitotic centrosomes pathway
Cell Cycle pathway
M Phase pathway
Mitotic G2-G2/M phases pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.7058
RefSeq NM_001100321
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas