InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CYP26A1

Summary

InnateDB Gene

IDBG-637647.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP26A1

Gene Name

cytochrome P450, family 26, subfamily A, polypeptide 1 isoform 1

Synonyms

CYP26

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021118

Encoded Proteins

IDBP-689669

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095596:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:14460222-14463796

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028140

ENSBTAP00000028140

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008401	retinoic acid 4-hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0007417	central nervous system development
GO:0009952	anterior/posterior pattern specification
GO:0014032	neural crest cell development
GO:0034653	retinoic acid catabolic process
GO:0042573	retinoic acid metabolic process
GO:0048384	retinoic acid receptor signaling pathway
GO:0055114	oxidation-reduction process
GO:0071300	cellular response to retinoic acid