Homo sapiens Gene: CYP26A1
Summary
InnateDB Gene IDBG-82645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP26A1
Gene Name cytochrome P450, family 26, subfamily A, polypeptide 1
Synonyms CP26; CYP26; P450RAI; P450RAI1;
Species Homo sapiens
Ensembl Gene ENSG00000095596
Encoded Proteins
cytochrome P450, family 26, subfamily A, polypeptide 1
cytochrome P450, family 26, subfamily A, polypeptide 1
cytochrome P450, family 26, subfamily A, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93073475-93077890
Strand Forward strand
Band q23.33
Transcripts
ENST00000371531 ENSP00000360586
ENST00000224356 ENSP00000224356
ENST00000622925
ENST00000624589 ENSP00000485126
ENST00000623162
ENST00000625202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005506 iron ion binding
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0006766 vitamin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007417 central nervous system development
GO:0008152 metabolic process
GO:0009952 anterior/posterior pattern specification
GO:0014032 neural crest cell development
GO:0034653 retinoic acid catabolic process
GO:0042573 retinoic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0048384 retinoic acid receptor signaling pathway
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Vitamins pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Retinol metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000783 NM_057157
HUGO
OMIM
CCDS CCDS7426 CCDS7427
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas