InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL2RB

Summary

InnateDB Gene

IDBG-638176.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2RB

Gene Name

Uncharacterized protein

Synonyms

IL2RB

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016345

Encoded Proteins

IDBP-690240

interleukin 2 receptor, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 8700888

[Homo sapiens] IL2RB is phosphorylated by JAK1and different IL2RB tyrosines couple to at least two signalling pathways (JAK-STAT and SHC-coupled) and synergistically mediate IL2-induced proliferation.

PMID 8041779

[Homo sapiens] IL2RB physically associates with JAK1 suggesting that regulation of JAK1 may be linked to IL2 induced signal transduction.

PMID 26668377

[Mus musculus] Selective loss of the histone-lysine N-methyltransferase Ezh2 (enhancer of zeste homolog 2) or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100385:
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:75927872-75939915

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021747

ENSBTAP00000021747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding