Homo sapiens Gene: IL2RB
Summary
InnateDB Gene IDBG-6418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2RB
Gene Name interleukin 2 receptor, beta
Synonyms CD122; IL15RB; P70-75;
Species Homo sapiens
Ensembl Gene ENSG00000100385
Encoded Proteins
interleukin 2 receptor, beta
interleukin 2 receptor, beta
interleukin 2 receptor, beta
interleukin 2 receptor, beta
interleukin 2 receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL2RB is phosphorylated by JAK1and different IL2RB tyrosines couple to at least two signalling pathways (JAK-STAT and SHC-coupled) and synergistically mediate IL2-induced proliferation.
IL2RB physically associates with JAK1 suggesting that regulation of JAK1 may be linked to IL2 induced signal transduction.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Selective loss of the histone-lysine N-methyltransferase Ezh2 (enhancer of zeste homolog 2) or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.
Entrez Gene
Summary The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37125838-37175054
Strand Reverse strand
Band q12.3
Transcripts
ENST00000216223 ENSP00000216223
ENST00000453962 ENSP00000403731
ENST00000429622 ENSP00000402685
ENST00000440958 ENSP00000400416
ENST00000445595 ENSP00000401020
ENST00000483573
ENST00000461607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 44 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004911 interleukin-2 receptor activity
GO:0005515 protein binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0006461 protein complex assembly
GO:0007165 signal transduction
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL2 pathway
IL5 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
PID BIOCARTA
Il 2 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
PID NCI
IL2-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.474787
RefSeq NM_000878
HUGO
OMIM
CCDS CCDS13942
HPRD 00896
IMGT
EMBL
GenPept
RNA Seq Atlas