InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL2RB

Summary

InnateDB Gene

IDBG-6418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2RB

Gene Name

interleukin 2 receptor, beta

Synonyms

CD122; IL15RB; P70-75

Species

Homo sapiens

Ensembl Gene

ENSG00000100385

Encoded Proteins

IDBP-6420

interleukin 2 receptor, beta

IDBP-375207

interleukin 2 receptor, beta

IDBP-375209

interleukin 2 receptor, beta

IDBP-375211

interleukin 2 receptor, beta

IDBP-375213

interleukin 2 receptor, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 8700888

IL2RB is phosphorylated by JAK1and different IL2RB tyrosines couple to at least two signalling pathways (JAK-STAT and SHC-coupled) and synergistically mediate IL2-induced proliferation.

PMID 8041779

IL2RB physically associates with JAK1 suggesting that regulation of JAK1 may be linked to IL2 induced signal transduction.

InnateDB Annotation from Orthologs

Summary

PMID 26668377

[Mus musculus] Selective loss of the histone-lysine N-methyltransferase Ezh2 (enhancer of zeste homolog 2) or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.

Entrez Gene

Summary

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:37125838-37175054

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000216223	ENSP00000216223
ENST00000453962	ENSP00000403731
ENST00000429622	ENSP00000402685
ENST00000440958	ENSP00000400416
ENST00000445595	ENSP00000401020
ENST00000483573
ENST00000461607

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	44 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0038110	interleukin-2-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)