Bos taurus Gene: TOB1
Summary
InnateDB Gene IDBG-638481.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOB1
Gene Name protein Tob1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000546
Encoded Proteins
transducer of ERBB2, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141232:
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:36512064-36515184
Strand Forward strand
Band
Transcripts
ENSBTAT00000000714 ENSBTAP00000000714
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0046332 SMAD binding
Biological Process
GO:0007184 SMAD protein import into nucleus
GO:0008285 negative regulation of cell proliferation
GO:0017148 negative regulation of translation
GO:0030514 negative regulation of BMP signaling pathway
GO:0045668 negative regulation of osteoblast differentiation
GO:0060212 negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
RNA degradation pathway
RNA degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.65611 Bt.88346
RefSeq NM_001077075 XM_005195701
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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