Version 5.4
Mus musculus Gene: Tob1
Summary
InnateDB Gene IDBG-208788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tob1
Gene Name transducer of ErbB-2.1
Synonyms Tob; Trob
Species Mus musculus
Ensembl Gene ENSMUSG00000037573
Encoded Proteins
IDBP-208790
transducer of ErbB-2.1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141232:
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94211454-94215495
Strand Forward strand
Band D
Transcripts
ENSMUST00000041589 ENSMUSP00000036039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0046332 SMAD binding
Biological Process
GO:0007184 SMAD protein import into nucleus
GO:0008285 negative regulation of cell proliferation
GO:0017148 negative regulation of translation
GO:0030514 negative regulation of BMP signaling pathway
GO:0045668 negative regulation of osteoblast differentiation
GO:0060212 negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141232
View Gene Order
ENSBTAG00000000546
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q61471
TrEMBL
UniProt Splice Variant
Entrez Gene 22057
UniGene Mm.259673
RefSeq NM_009427
OMIM
CCDS CCDS25250
HPRD
IMGT
MGI ID MGI:1349721
MGI Symbol Tob1
EMBL AL645846 BC082588 D78382
GenPept AAH82588 BAA11384
RNA Seq Atlas 22057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca