Version 5.4
Homo sapiens Gene: TOB1
Summary
InnateDB Gene IDBG-59376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOB1
Gene Name transducer of ERBB2, 1
Synonyms APRO6; PIG49; TOB; TROB; TROB1
Species Homo sapiens
Ensembl Gene ENSG00000141232
Encoded Proteins
IDBP-59378
transducer of ERBB2, 1
IDBP-478234
transducer of ERBB2, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50862223-50867978
Strand Reverse strand
Band q21.33
Transcripts
ENST00000268957 ENSP00000268957
ENST00000499247 ENSP00000427695
ENST00000509385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0046332 SMAD binding
Biological Process
GO:0007184 SMAD protein import into nucleus
GO:0008285 negative regulation of cell proliferation
GO:0009967 positive regulation of signal transduction
GO:0017148 negative regulation of translation
GO:0030514 negative regulation of BMP signaling pathway
GO:0045668 negative regulation of osteoblast differentiation
GO:0060212 negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037573
View Gene Order
ENSBTAG00000000546
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt P50616
TrEMBL
UniProt Splice Variant
Entrez Gene 10140
UniGene Hs.531550 Hs.743451
RefSeq NM_001243877 NM_001243885 NM_005749
HUGO HGNC:11979
OMIM 605523
CCDS CCDS11576
HPRD
IMGT
EMBL AK313904 BC031406 BC070493 BC098415 BT019380 BT019381 CH471109 CR536487 CR541686 D38305
GenPept AAH31406 AAH70493 AAH98415 AAV38187 AAV38188 BAA07423 BAG36627 CAG38726 CAG46487 EAW94577 EAW94578
RNA Seq Atlas 10140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca