InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZEB1

Summary

InnateDB Gene

IDBG-638511.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZEB1

Gene Name

zinc finger E-box-binding homeobox 1

Synonyms

deltaEF1; TCF8

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020053

Encoded Proteins

IDBP-690601

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148516:
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:34063175-34261299

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000038847

ENSBTAP00000038655

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0010464	regulation of mesenchymal cell proliferation
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0033081	regulation of T cell differentiation in thymus
GO:0045666	positive regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048513	organ development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048752	semicircular canal morphogenesis
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051216	cartilage development
GO:0071230	cellular response to amino acid stimulus
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000148516

View Gene Order

ENSMUSG00000024238

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

ilk_pathway

Integrin-linked kinase signaling

Cross-References

SwissProt

TrEMBL

F1N264

UniProt Splice Variant

Entrez Gene

535183

UniGene

Bt.107873 Bt.5549

RefSeq

NM_001206590 XM_005214364 XM_005214365 XM_005214366

HUGO

HGNC:11642

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02035609 DAAA02035610 DAAA02035611 DAAA02035612 DAAA02035613

GenPept

RNA Seq Atlas

535183