Version 5.4
Bos taurus Gene: SPOP
Summary
InnateDB Gene IDBG-638797.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPOP
Gene Name Speckle-type POZ protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005824
Encoded Proteins
IDBP-690901
Speckle-type POZ protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121067:
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:37570928-37653473
Strand Forward strand
Band
Transcripts
ENSBTAT00000007660 ENSBTAP00000007660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000121067
View Gene Order
ENSMUSG00000057522
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt Q0VCW1
TrEMBL
UniProt Splice Variant
Entrez Gene 530618
UniGene Bt.22571 Bt.68043
RefSeq NM_001075936 XM_005220571 XM_005220572
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119970
GenPept AAI19971
RNA Seq Atlas 530618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca