InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPS8

Summary

InnateDB Gene

IDBG-639166.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPS8

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000369

Encoded Proteins

IDBP-691360

epidermal growth factor receptor kinase substrate 8

IDBP-691363

epidermal growth factor receptor kinase substrate 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22493489

[Homo sapiens] EPS8 is a key regulator of the LPS-induced TLR4-MYD88 interaction and directly contributes to phagocytosis in macrophages. (Demonstrated in mice)

PMID 22493489

[Mus musculus] Eps8 is a key regulator of the LPS-induced Tlr4-Myd88 interaction and directly contributes to phagocytosis in macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151491:
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:94673755-94749093

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000479	ENSBTAP00000000479
ENSBTAT00000029983	ENSBTAP00000029971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0008344	adult locomotory behavior
GO:0008360	regulation of cell shape
GO:0010458	exit from mitosis
GO:0016601	Rac protein signal transduction
GO:0030832	regulation of actin filament length
GO:0031532	actin cytoskeleton reorganization
GO:0036336	dendritic cell migration
GO:0048149	behavioral response to ethanol
GO:0051016	barbed-end actin filament capping
GO:0051017	actin filament bundle assembly
GO:0051764	actin crosslink formation
GO:0070358	actin polymerization-dependent cell motility

Cellular Component

GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0032420	stereocilium
GO:0032587	ruffle membrane
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000151491

View Gene Order

ENSMUSG00000015766

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

rac1_reg_pathway

Regulation of RAC1 activity

erbb1_downstream_pathway

ErbB1 downstream signaling

cdc42_pathway

CDC42 signaling events

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.12691

RefSeq

XM_003582254 XM_003586110 XM_005198398 XM_005198399 XM_005198400 XM_005198401 XM_005198402 XM_005206994 XM_005206995 XM_005206996 XM_005206997 XM_005206998

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas