InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LOC790544

Summary

InnateDB Gene

IDBG-639264.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOC790544

Gene Name

non-specific lipid-transfer protein

Synonyms

SCPX

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003746

Encoded Proteins

IDBP-691414

non-specific lipid-transfer protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116171:
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:93846489-93968364

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004879

ENSBTAP00000004879

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008526	phosphatidylinositol transporter activity
GO:0015485	cholesterol binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0036042	long-chain fatty acyl-CoA binding
GO:0070538	oleic acid binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0007031	peroxisome organization
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0032385	positive regulation of intracellular cholesterol transport
GO:0032959	inositol trisphosphate biosynthetic process
GO:0045940	positive regulation of steroid metabolic process
GO:0072659	protein localization to plasma membrane
GO:1901373	lipid hydroperoxide transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome