InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scp2

Summary

InnateDB Gene

IDBG-172393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scp2

Gene Name

sterol carrier protein 2, liver

Synonyms

AA409774; AA409893; C76618; C79031; ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028603

Encoded Proteins

IDBP-172395

sterol carrier protein 2, liver

IDBP-268220

sterol carrier protein 2, liver

IDBP-535359

sterol carrier protein 2, liver

IDBP-531953

sterol carrier protein 2, liver

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116171:
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:108043839-108144998

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030340	ENSMUSP00000030340
ENSMUST00000106701	ENSMUSP00000102312
ENSMUST00000145721
ENSMUST00000122878
ENSMUST00000135379
ENSMUST00000149106	ENSMUSP00000121673
ENSMUST00000123792
ENSMUST00000143340
ENSMUST00000130776	ENSMUSP00000123630

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008526	phosphatidylinositol transporter activity
GO:0015485	cholesterol binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0033814	propanoyl-CoA C-acyltransferase activity
GO:0036042	long-chain fatty acyl-CoA binding
GO:0050632	propionyl-CoA C2-trimethyltridecanoyltransferase activity
GO:0070538	oleic acid binding

Biological Process

GO:0006637	acyl-CoA metabolic process
GO:0006694	steroid biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0007031	peroxisome organization
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0032385	positive regulation of intracellular cholesterol transport
GO:0032959	inositol trisphosphate biosynthetic process
GO:0045940	positive regulation of steroid metabolic process
GO:0072659	protein localization to plasma membrane
GO:1901373	lipid hydroperoxide transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome