InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NECAP1

Summary

InnateDB Gene

IDBG-639814.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NECAP1

Gene Name

Adaptin ear-binding coat-associated protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020237

Encoded Proteins

IDBP-692007

Adaptin ear-binding coat-associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089818:
This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:102050908-102062664

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026951

ENSBTAP00000026951

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006897	endocytosis
GO:0015031	protein transport

Cellular Component

GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030125	clathrin vesicle coat
GO:0030665	clathrin-coated vesicle membrane
GO:0031410	cytoplasmic vesicle