InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHD4

Summary

InnateDB Gene

IDBG-640327.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD4

Gene Name

chromodomain-helicase-DNA-binding protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014734

Encoded Proteins

IDBP-692707

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111642:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104186061-104214563

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019612

ENSBTAP00000019612

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008026	ATP-dependent helicase activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031492	nucleosomal DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006325	chromatin organization
GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0043044	ATP-dependent chromatin remodeling
GO:0051225	spindle assembly

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex