Bos taurus Gene: BT.105440
Summary
InnateDB Gene IDBG-640935.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.105440
Gene Name sequestosome-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015591
Encoded Proteins
sequestosome-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SQSTM1 (p62) targets invading bacteria to the autophagy pathway and its expression is required for efficient autophagy of bacteria, as well as restriction of their intracellular replication.
[Homo sapiens] SQSTM1 is a key intracellular target of innate defence regulator-1 (IDR-1), a synthetic peptide.
[Homo sapiens] SQSTM1 has bactericidal properties where it brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides.
[Homo sapiens] SQSTM1 and HDAC6 are important determinants of aggregated localization of MyD88 and MyD88 activation initiates a polyubiquitinated protein accumulating pathway that modulates MyD88-dependent signal transduction.
[Homo sapiens] SQSTM1 is required for TLR4-mediated autophagy. TLR4-driven induction of SQSTM1 plays an essential role in the formation and the autophagy degradation of aggresome-like induced structures, which might be critical for regulating host defence.
[Homo sapiens] SQSTM1 and CALCOCO2 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the TMEM173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes. (Demonstrated in mouse)
[Mus musculus] Sqstm1 is required for Tlr4-mediated autophagy. Tlr4-driven induction of Sqstm1 plays an essential role in the formation and the autophagy degradation of aggresome-like induced structures, which might be critical for regulating host defense.
[Mus musculus] Sqstm1 and Calcoco2 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the Tmem173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes.
[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy.
[Mus musculus] Sqstm1 captures Tnfaip3, an NFkB inhibitor, and sequesters it in the autophagosome. This allows macrophages to release chemokines that recruit neutrophils and boost antifungal immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161011:
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:1334566-1346051
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020709 ENSBTAP00000020709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 174 interaction(s) predicted by orthology.
Predicted by orthology
Total 174 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0006914 autophagy
GO:0016239 positive regulation of macroautophagy
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016605 PML body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
IL1 pathway
RANKL pathway
REACTOME
Signalling by NGF pathway
p75NTR recruits signalling complexes pathway
Cytokine Signaling in Immune system pathway
NF-kB is activated and signals survival pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
Immune System pathway
NRIF signals cell death from the nucleus pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
p75NTR recruits signalling complexes pathway
Signaling by Interleukins pathway
p75NTR signals via NF-kB pathway
Signalling by NGF pathway
NF-kB is activated and signals survival pathway
Interleukin-1 signaling pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
NRIF signals cell death from the nucleus pathway
KEGG
Osteoclast differentiation pathway
Osteoclast differentiation pathway
INOH
PID BIOCARTA
PID NCI
IL1-mediated signaling events
TNF receptor signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL F1MIE2
UniProt Splice Variant
Entrez Gene 338045
UniGene Bt.105440 Bt.28031
RefSeq NM_176641
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018966
GenPept
RNA Seq Atlas 338045
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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