InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105440

Summary

InnateDB Gene

IDBG-640935.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105440

Gene Name

sequestosome-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015591

Encoded Proteins

IDBP-693238

sequestosome-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19812211

[Homo sapiens] SQSTM1 (p62) targets invading bacteria to the autophagy pathway and its expression is required for efficient autophagy of bacteria, as well as restriction of their intracellular replication.

PMID 19850933

[Homo sapiens] SQSTM1 is a key intracellular target of innate defence regulator-1 (IDR-1), a synthetic peptide.

PMID 20206555

[Homo sapiens] SQSTM1 has bactericidal properties where it brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides.

PMID 20837465

[Homo sapiens] SQSTM1 and HDAC6 are important determinants of aggregated localization of MyD88 and MyD88 activation initiates a polyubiquitinated protein accumulating pathway that modulates MyD88-dependent signal transduction.

PMID 21220332

[Homo sapiens] SQSTM1 is required for TLR4-mediated autophagy. TLR4-driven induction of SQSTM1 plays an essential role in the formation and the autophagy degradation of aggresome-like induced structures, which might be critical for regulating host defence.

PMID 22901810

[Homo sapiens] SQSTM1 and CALCOCO2 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the TMEM173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes. (Demonstrated in mouse)

PMID 21220332

[Mus musculus] Sqstm1 is required for Tlr4-mediated autophagy. Tlr4-driven induction of Sqstm1 plays an essential role in the formation and the autophagy degradation of aggresome-like induced structures, which might be critical for regulating host defense.

PMID 22901810

[Mus musculus] Sqstm1 and Calcoco2 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the Tmem173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes.

PMID 24011591

[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy.

PMID 25609235

[Mus musculus] Sqstm1 captures Tnfaip3, an NFkB inhibitor, and sequesters it in the autophagosome. This allows macrophages to release chemokines that recruit neutrophils and boost antifungal immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161011:
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:1334566-1346051

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020709

ENSBTAP00000020709

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 174 interaction(s) predicted by orthology.

Predicted by orthology
Total	174 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0042802	identical protein binding
GO:0043130	ubiquitin binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0006914	autophagy
GO:0016239	positive regulation of macroautophagy
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0016234	inclusion body
GO:0016235	aggresome
GO:0016605	PML body
GO:0070062	extracellular vesicular exosome