|Homo sapiens Gene: SQSTM1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||sequestosome 1|
|Synonyms||A170; OSIL; p60; p62; p62B; PDB3; ZIP3|
|Useful resources||Stemformatics EHFPI ImmGen|
SQSTM1 (p62) targets invading bacteria to the autophagy pathway and its expression is required for efficient autophagy of bacteria, as well as restriction of their intracellular replication.
SQSTM1 is a key intracellular target of innate defence regulator-1 (IDR-1), a synthetic peptide.
SQSTM1 has bactericidal properties where it brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides.
SQSTM1 and HDAC6 are important determinants of aggregated localization of MyD88 and MyD88 activation initiates a polyubiquitinated protein accumulating pathway that modulates MyD88-dependent signal transduction.
SQSTM1 is required for TLR4-mediated autophagy. TLR4-driven induction of SQSTM1 plays an essential role in the formation and the autophagy degradation of aggresome-like induced structures, which might be critical for regulating host defence.
SQSTM1 and CALCOCO2 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the TMEM173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes. (Demonstrated in mouse)
|InnateDB Annotation from Orthologs|
[Mus musculus] Sqstm1 is required for Tlr4-mediated autophagy. Tlr4-driven induction of Sqstm1 plays an essential role in the formation and the autophagy degradation of aggresome-like induced structures, which might be critical for regulating host defense.
[Mus musculus] Sqstm1 and Calcoco2 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the Tmem173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes.
[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy.
[Mus musculus] Sqstm1 captures Tnfaip3, an NFkB inhibitor, and sequesters it in the autophagosome. This allows macrophages to release chemokines that recruit neutrophils and boost antifungal immunity.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
|Genomic Location||Chromosome 5:179806398-179838078|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 502 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Not yet available
Interleukin-1 signaling pathway
p75NTR recruits signalling complexes pathway
NF-kB is activated and signals survival pathway
NRIF signals cell death from the nucleus pathway
Signalling by NGF pathway
Cytokine Signaling in Immune system pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
Immune System pathway
Signaling by Interleukins pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Osteoclast differentiation pathway
IL1-mediated signaling events
TNF receptor signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
|UniProt Splice Variant|
|RefSeq||NM_001142298 NM_001142299 NM_003900|
|RNA Seq Atlas|