InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FSCN1

Summary

InnateDB Gene

IDBG-641080.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FSCN1

Gene Name

fascin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003191

Encoded Proteins

IDBP-693402

fascin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24244012

[Mus musculus] Fscn1 contributes to the survival of dendritic cells against Listeria monocytogenes infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075618:
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin\'s lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:39292721-39302192

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004145

ENSBTAP00000004145

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0048870	cell motility
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0030175	filopodium
GO:0070062	extracellular vesicular exosome
GO:0071437	invadopodium

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000075618

View Gene Order

ENSMUSG00000029581

View Gene Order

Cross-References

SwissProt

TrEMBL

Q3MHK9

UniProt Splice Variant

Entrez Gene

507342

UniGene

Bt.112129 Bt.12445 Bt.71994

RefSeq

NM_001035045

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105199 DAAA02058349

GenPept

AAI05200

RNA Seq Atlas

507342