Version 5.4
Mus musculus Gene: Fscn1
Summary
InnateDB Gene IDBG-207523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fscn1
Gene Name fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
Synonyms AI663989; Fan1; fascin-1
Species Mus musculus
Ensembl Gene ENSMUSG00000029581
Encoded Proteins
IDBP-207525
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
IDBP-533300
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
IDBP-540715
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
IDBP-537091
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
IDBP-539043
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24244012
Fscn1 contributes to the survival of dendritic cells against Listeria monocytogenes infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075618:
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin\'s lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142960343-142973185
Strand Forward strand
Band G2
Transcripts
ENSMUST00000031565 ENSMUSP00000031565
ENSMUST00000129306 ENSMUSP00000122862
ENSMUST00000150622 ENSMUSP00000123347
ENSMUST00000137552 ENSMUSP00000119590
ENSMUST00000139131 ENSMUSP00000115116
ENSMUST00000135293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0030674 protein binding, bridging
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0045087 innate immune response (InnateDB)
GO:0048870 cell motility
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0030175 filopodium
GO:0070062 extracellular vesicular exosome
GO:0071437 invadopodium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000075618
View Gene Order
ENSBTAG00000003191
Not yet available
Cross-References
SwissProt Q61553
TrEMBL D3YWW3 D3YZR7 D3Z1X1
UniProt Splice Variant
Entrez Gene 14086
UniGene Mm.289707
RefSeq NM_007984
OMIM
CCDS CCDS19834
HPRD
IMGT
MGI ID MGI:1352745
MGI Symbol Fscn1
EMBL AC144818 AK167670 BC010338 BC037137 BC052408 L33726 U90355
GenPept AAB41126 AAB58784 AAH10338 AAH37137 AAH52408 BAE39719
RNA Seq Atlas 14086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca