Homo sapiens Gene: FSCN1
Summary
InnateDB Gene IDBG-7693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSCN1
Gene Name fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
Synonyms FAN1; HSN; p55; SNL;
Species Homo sapiens
Ensembl Gene ENSG00000075618
Encoded Proteins
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Fscn1 contributes to the survival of dendritic cells against Listeria monocytogenes infection.
Entrez Gene
Summary This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin\'s lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5592823-5606655
Strand Forward strand
Band p22.1
Transcripts
ENST00000382361 ENSP00000371798
ENST00000405801 ENSP00000383982
ENST00000444748 ENSP00000404506
ENST00000447103 ENSP00000409967
ENST00000473330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0030674 protein binding, bridging
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0048870 cell motility
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0030175 filopodium
GO:0070062 extracellular vesicular exosome
GO:0071437 invadopodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q16658
TrEMBL B3KTA3 B3KTM9 C9JFC0 C9JPH9
UniProt Splice Variant
Entrez Gene 6624
UniGene Hs.118400 Hs.645050 Hs.739284
RefSeq NM_003088
HUGO HGNC:11148
OMIM 602689
CCDS CCDS5342
HPRD
IMGT
EMBL AC006483 AK095254 AK095830 AK316607 AY044229 BC000521 BC006304 BC007539 BC007643 BC007948 BC007988 BT006636 CH471144 U03057 U09873
GenPept AAA62201 AAA86442 AAH00521 AAH06304 AAH07539 AAH07643 AAH07948 AAH07988 AAL01526 AAP35282 BAG38194 BAG53015 BAG53141 EAW87346
RNA Seq Atlas 6624