InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FSCN1

Summary

InnateDB Gene

IDBG-7693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FSCN1

Gene Name

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Synonyms

FAN1; HSN; p55; SNL

Species

Homo sapiens

Ensembl Gene

ENSG00000075618

Encoded Proteins

IDBP-7695

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

IDBP-292649

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

IDBP-363015

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

IDBP-363018

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24244012

[Mus musculus] Fscn1 contributes to the survival of dendritic cells against Listeria monocytogenes infection.

Entrez Gene

Summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin\'s lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:5592823-5606655

Strand

Forward strand

Band

p22.1

Transcripts

ENST00000382361	ENSP00000371798
ENST00000405801	ENSP00000383982
ENST00000444748	ENSP00000404506
ENST00000447103	ENSP00000409967
ENST00000473330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0008283	cell proliferation
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0048870	cell motility
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0030175	filopodium
GO:0070062	extracellular vesicular exosome
GO:0071437	invadopodium

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029581

View Gene Order

ENSBTAG00000003191

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.118400 Hs.645050 Hs.739284

RefSeq

NM_003088

HUGO

OMIM

CCDS

CCDS5342

HPRD

04068

IMGT

EMBL

GenPept

RNA Seq Atlas