InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ERN1

Summary

InnateDB Gene

IDBG-641835.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERN1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016799

Encoded Proteins

IDBP-694249

endoplasmic reticulum to nucleus signaling 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20533428

[Homo sapiens] ERN1 (IRE1)/XBP1-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.

PMID 22883233

[Homo sapiens] Hyperactivated ERN1 (IRE1α) increases TXNIP mRNA stability by reducing levels of a TXNIP destabilizing microRNA, miR-17. In turn, elevated TXNIP protein activates the NLRP3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion.

PMID 23684307

[Homo sapiens] ERN1 binds to cholera toxin in the endoplasmic reticulum to activate RIG-I innate immune signalling.

PMID 22883233

[Mus musculus] Hyperactivated Ern1 (IRE1α) increases Txnip mRNA stability by reducing levels of a Txnip destabilizing microRNA, miR-17. In turn, elevated Txnip protein activates the Nlrp3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion. (Demonstrated in human)

PMID 26173697

[Mus musculus] ERN1-mediated persistent reactive oxygen species generation is a mechanism used by macrophages to kill bacterial pathogens that evade the initial oxidative burst.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178607:
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48924511-48971838

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022347

ENSBTAP00000022347

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004519	endonuclease activity
GO:0004521	endoribonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0042802	identical protein binding

Biological Process

GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0046777	protein autophosphorylation
GO:0070055	HAC1-type intron splice site recognition and cleavage
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane