InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ern1

Summary

InnateDB Gene

IDBG-213476.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ern1

Gene Name

endoplasmic reticulum (ER) to nucleus signalling 1

Synonyms

9030414B18Rik; AI225830; C85377; Ire1a; Ire1alpha; Ire1p

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020715

Encoded Proteins

IDBP-213478

endoplasmic reticulum (ER) to nucleus signalling 1

IDBP-268005

endoplasmic reticulum (ER) to nucleus signalling 1

IDBP-268007

endoplasmic reticulum (ER) to nucleus signalling 1

IDBP-268009

endoplasmic reticulum (ER) to nucleus signalling 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22883233

Hyperactivated Ern1 (IRE1α) increases Txnip mRNA stability by reducing levels of a Txnip destabilizing microRNA, miR-17. In turn, elevated Txnip protein activates the Nlrp3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion. (Demonstrated in human)

PMID 26173697

ERN1-mediated persistent reactive oxygen species generation is a mechanism used by macrophages to kill bacterial pathogens that evade the initial oxidative burst.

InnateDB Annotation from Orthologs

Summary

PMID 20533428

[Homo sapiens] ERN1 (IRE1)/XBP1-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.

PMID 22883233

[Homo sapiens] Hyperactivated ERN1 (IRE1α) increases TXNIP mRNA stability by reducing levels of a TXNIP destabilizing microRNA, miR-17. In turn, elevated TXNIP protein activates the NLRP3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion.

PMID 23684307

[Homo sapiens] ERN1 binds to cholera toxin in the endoplasmic reticulum to activate RIG-I innate immune signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178607:
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106394650-106487852

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001059	ENSMUSP00000001059
ENSMUST00000106801	ENSMUSP00000102413
ENSMUST00000106800	ENSMUSP00000102412
ENSMUST00000106799	ENSMUSP00000102411
ENSMUST00000131895

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004519	endonuclease activity
GO:0004521	endoribonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0070055	HAC1-type intron splice site recognition and cleavage
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000178607

View Gene Order

ENSBTAG00000016799

Not yet available

Pathways

NETPATH

REACTOME

REACT_239697

Unfolded Protein Response (UPR) pathway

REACT_247926

Metabolism of proteins pathway

REACT_231085

IRE1alpha activates chaperones pathway

KEGG

mmu05010

Alzheimer's disease pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.340943 Mm.403353

RefSeq

NM_023913

OMIM

CCDS

CCDS25556

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas