Version 5.4
Bos taurus Gene: BT.66090
Summary
InnateDB Gene IDBG-642000.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.66090
Gene Name SH3 domain-binding protein 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013869
Encoded Proteins
IDBP-694410
SH3 domain-binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130147:
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:115210340-115232304
Strand Forward strand
Band
Transcripts
ENSBTAT00000018420 ENSBTAP00000018420
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0042802 identical protein binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0010508 positive regulation of autophagy
GO:0030308 negative regulation of cell growth
GO:0032007 negative regulation of TOR signaling
GO:0034260 negative regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0061462 protein localization to lysosome
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130147
View Gene Order
ENSMUSG00000036206
View Gene Order
Cross-References
SwissProt
TrEMBL E1BB46
UniProt Splice Variant
Entrez Gene 520462
UniGene Bt.66090
RefSeq NM_001144088 XM_005204953 XM_005204954 XM_005204955 XM_005204956 XM_005204957 XM_005204958 XM_005204959
HUGO HGNC:10826
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009296
GenPept
RNA Seq Atlas 520462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca