Bos taurus Gene: TWIST2
InnateDB Gene IDBG-642241.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TWIST2
Gene Name twist-related protein 2
Species Bos taurus
Ensembl Gene ENSBTAG00000021444
Encoded Proteins
twist-related protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000233608:
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:118630617-118690526
Strand Forward strand
ENSBTAT00000028589 ENSBTAP00000028589
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0043392 negative regulation of DNA binding
GO:0044092 negative regulation of molecular function
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060325 face morphogenesis
GO:0061303 cornea development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Mus musculus
Homo sapiens
Gene ID
Gene Order
UniProt Splice Variant
Entrez Gene 540060
UniGene Bt.87327
RefSeq NM_001083748
EMBL BC134662 DAAA02009403 DAAA02009404 DAAA02009405 DAAA02009406 DAAA02009407 DAAA02009408
GenPept AAI34663
RNA Seq Atlas 540060