Bos taurus Gene: CAPN10
Summary
InnateDB Gene IDBG-642358.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN10
Gene Name Uncharacterized protein
Synonyms CAPN10;
Species Bos taurus
Ensembl Gene ENSBTAG00000002809
Encoded Proteins
calpain 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142330:
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:120332023-120339480
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003637 ENSBTAP00000003637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0031532 actin cytoskeleton reorganization
GO:0032024 positive regulation of insulin secretion
GO:0032388 positive regulation of intracellular transport
GO:0032869 cellular response to insulin stimulus
GO:0046326 positive regulation of glucose import
GO:0097050 type B pancreatic cell apoptotic process
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005623 cell
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F1MBN8
UniProt Splice Variant
Entrez Gene 789674
UniGene Bt.2617
RefSeq XM_002686618 XM_005197979
HUGO HGNC:1477
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009499
GenPept
RNA Seq Atlas 789674
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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