Homo sapiens Gene: KCNC3
Summary
InnateDB Gene IDBG-64255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNC3
Gene Name potassium voltage-gated channel, Shaw-related subfamily, member 3
Synonyms KSHIIID; KV3.3; SCA13;
Species Homo sapiens
Ensembl Gene ENSG00000131398
Encoded Proteins
potassium voltage-gated channel, Shaw-related subfamily, member 3
potassium voltage-gated channel, Shaw-related subfamily, member 3
potassium voltage-gated channel, Shaw-related subfamily, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq, Jul 2008]
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50311937-50333515
Strand Reverse strand
Band q13.33
Transcripts
ENST00000376959 ENSP00000366158
ENST00000474951 ENSP00000432438
ENST00000477616 ENSP00000434241
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0008219 cell death
GO:0034765 regulation of ion transmembrane transport
GO:0046928 regulation of neurotransmitter secretion
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0030673 axolemma
GO:0031594 neuromuscular junction
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Voltage gated Potassium channels pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467146
RefSeq NM_004977 XM_006723203
HUGO
OMIM
CCDS CCDS12793
HPRD 08886
IMGT
EMBL
GenPept
RNA Seq Atlas