InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RPTOR

Summary

InnateDB Gene

IDBG-642599.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPTOR

Gene Name

regulatory-associated protein of mTOR

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002883

Encoded Proteins

IDBP-695084

regulatory associated protein of MTOR, complex 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141564:
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:52308519-52629957

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003739

ENSBTAP00000003739

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001030	RNA polymerase III type 1 promoter DNA binding
GO:0001031	RNA polymerase III type 2 promoter DNA binding
GO:0001032	RNA polymerase III type 3 promoter DNA binding
GO:0001156	TFIIIC-class transcription factor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0008361	regulation of cell size
GO:0016049	cell growth
GO:0031669	cellular response to nutrient levels
GO:0031929	TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0071230	cellular response to amino acid stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity