InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPTOR

Summary

InnateDB Gene

IDBG-71820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPTOR

Gene Name

regulatory associated protein of MTOR, complex 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000141564

Encoded Proteins

IDBP-71822

regulatory associated protein of MTOR, complex 1

IDBP-588496

regulatory associated protein of MTOR, complex 1

IDBP-762963

IDBP-760298

IDBP-761434

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:80544819-80966371

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000306801	ENSP00000307272
ENST00000544334	ENSP00000442479
ENST00000573746
ENST00000574767	ENSP00000459701
ENST00000573163
ENST00000572733
ENST00000577161
ENST00000575542
ENST00000573837
ENST00000576366	ENSP00000460940
ENST00000570891	ENSP00000460136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	127 [view]
Protein-Protein	127 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001030	RNA polymerase III type 1 promoter DNA binding
GO:0001031	RNA polymerase III type 2 promoter DNA binding
GO:0001032	RNA polymerase III type 3 promoter DNA binding
GO:0001156	TFIIIC-class transcription factor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0007050	cell cycle arrest
GO:0008286	insulin receptor signaling pathway
GO:0008361	regulation of cell size
GO:0016049	cell growth
GO:0031669	cellular response to nutrient levels
GO:0031929	TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0042325	regulation of phosphorylation
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0071230	cellular response to amino acid stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0030425	dendrite
GO:0031931	TORC1 complex
GO:0043025	neuronal cell body