Homo sapiens Gene: RPTOR
Summary
InnateDB Gene IDBG-71820.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPTOR
Gene Name regulatory associated protein of MTOR, complex 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141564
Encoded Proteins
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:80544819-80966371
Strand Forward strand
Band q25.3
Transcripts
ENST00000306801 ENSP00000307272
ENST00000544334 ENSP00000442479
ENST00000573746
ENST00000574767 ENSP00000459701
ENST00000573163
ENST00000572733
ENST00000577161
ENST00000575542
ENST00000573837
ENST00000576366 ENSP00000460940
ENST00000570891 ENSP00000460136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 127 [view]
Protein-Protein 127 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
GO:0001156 TFIIIC-class transcription factor binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007050 cell cycle arrest
GO:0008286 insulin receptor signaling pathway
GO:0008361 regulation of cell size
GO:0016049 cell growth
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0042325 regulation of phosphorylation
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0071230 cellular response to amino acid stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031931 TORC1 complex
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Cellular responses to stress pathway
PKB-mediated events pathway
mTOR signalling pathway
Release of eIF4E pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
S6K1-mediated signalling pathway
Insulin receptor signalling cascade pathway
HSF1-dependent transactivation pathway
IRS-related events triggered by IGF1R pathway
Cellular response to heat stress pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Signaling by Insulin receptor pathway
Regulation of AMPK activity via LKB1 pathway
KEGG
mTOR signaling pathway pathway
Insulin signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mTOR signaling pathway
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133044
RefSeq NM_001163034 NM_020761
HUGO
OMIM
CCDS CCDS11773 CCDS54175
HPRD 06184
IMGT
EMBL
GenPept
RNA Seq Atlas