Bos taurus Gene: NFATC2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-643253.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NFATC2 | ||||||||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000018270 | ||||||||||||||||||||||
Encoded Proteins |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] NFATC2 interacts with JUN to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
[Mus musculus] Nfatc2 is a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumorigenesis.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101096:
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 13:80015601-80114072 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
KitReceptor pathway
Wnt pathway
TCR pathway
BCR pathway
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REACTOME |
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
Innate Immune System pathway
Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
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KEGG |
VEGF signaling pathway pathway
Wnt signaling pathway pathway
Axon guidance pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
Axon guidance pathway
VEGF signaling pathway pathway
T cell receptor signaling pathway pathway
Wnt signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
B cell receptor signaling pathway pathway
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Noncanonical Wnt signaling pathway
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Bt.88008 | ||||||||||||||||||||||
RefSeq | XM_002692357 XM_005192517 XM_005192518 XM_005215064 XM_005215065 XM_608872 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||