Version 5.4
Bos taurus Gene: DMP1
Summary
InnateDB Gene IDBG-643326.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMP1
Gene Name dentin matrix acidic phosphoprotein 1 precursor
Synonyms DMP-1
Species Bos taurus
Ensembl Gene ENSBTAG00000019132
Encoded Proteins
IDBP-695883
dentin matrix acidic phosphoprotein 1 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152592:
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:104304075-104320863
Strand Forward strand
Band
Transcripts
ENSBTAT00000025468 ENSBTAP00000025468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0050840 extracellular matrix binding
Biological Process
GO:0001503 ossification
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000152592
View Gene Order
ENSMUSG00000029307
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196606
ECM proteoglycans pathway
KEGG
INOH
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL A6QNV1 F1MJM1
UniProt Splice Variant
Entrez Gene 281118
UniGene Bt.61485
RefSeq NM_174038
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149016 DAAA02018360
GenPept AAI49017
RNA Seq Atlas 281118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca