Bos taurus Gene: NFATC1
Summary
InnateDB Gene IDBG-643394.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFATC1
Gene Name Nuclear factor of activated T-cells, cytoplasmic 1
Synonyms NF-ATc; NF-ATc1; NFAT
Species Bos taurus
Ensembl Gene ENSBTAG00000000656
Encoded Proteins
Nuclear factor of activated T-cells, cytoplasmic 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131196:
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:1018253-1099817
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000859 ENSBTAP00000000859
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001837 epithelial to mesenchymal transition
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006816 calcium ion transport
GO:0007507 heart development
GO:0010628 positive regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0035556 intracellular signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Signaling by Wnt pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
Ca2+ pathway pathway
Signal Transduction pathway
beta-catenin independent WNT signaling pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
RANKL pathway
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
KEGG
Wnt signaling pathway pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
T cell receptor signaling pathway pathway
Wnt signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
Osteoclast differentiation pathway
INOH
PID NCI
Downstream signaling in na´ve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt P98201
TrEMBL G3XCF6
UniProt Splice Variant
Entrez Gene 511224
UniGene Bt.45162
RefSeq NM_001166615 XM_005223925
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02056013 DAAA02056014 DAAA02056015 DAAA02056016
GenPept
RNA Seq Atlas 511224