InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SOCS6

Summary

InnateDB Gene

IDBG-643512.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS6

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017412

Encoded Proteins

IDBP-696065

suppressor of cytokine signaling 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 14707129

[Homo sapiens] SOCS6 associates with KIT and regulates KIT receptor signalling and leads to MAPK activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170677:
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:7303047-7304704

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023144

ENSBTAP00000023144

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0010498	proteasomal protein catabolic process
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0050868	negative regulation of T cell activation