Version 5.4
Bos taurus Gene: EGFR
Summary
InnateDB Gene IDBG-644035.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGFR
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011628
Encoded Proteins
IDBP-696638
epidermal growth factor receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 11470832
[Homo sapiens] EGFR is the receptor for epidermal growth factor (EGF) and signalling through growth factor receptors controls diverse cell functions such as proliferation, migration, and differentiation.
PMID 15284024
[Homo sapiens] EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes.
PMID 18772136
[Homo sapiens] EGFR and TLR4 are activated by neutrophil elastase (ELA2) to produce IL8 through a novel metalloprotease pathway.
PMID 26055519
[Homo sapiens] Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
PMID 26055519
[Homo sapiens] Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
PMID 26243875
[Mus musculus] Il33-dependent group 2 innate lymphoid cells (ILC2s) signal via Areg-Egfr in damaged epithelia to restore epithelial barrier function and maintain tissue homeostasis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146648:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:892005-1069280
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015445 ENSBTAP00000015445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 336 interaction(s) predicted by orthology.
Predicted by orthology
Total 336 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007435 salivary gland morphogenesis
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0016310 phosphorylation
GO:0016337 single organismal cell-cell adhesion
GO:0021795 cerebral cortex cell migration
GO:0023014 signal transduction by phosphorylation
GO:0030335 positive regulation of cell migration
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0035413 positive regulation of catenin import into nucleus
GO:0042127 regulation of cell proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042327 positive regulation of phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048546 digestive tract morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0060571 morphogenesis of an epithelial fold
GO:0070141 response to UV-A
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030139 endocytic vesicle
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146648
View Gene Order
ENSMUSG00000020122
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_12578
GAB1 signalosome pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_121096
EGFR Transactivation by Gastrin pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_203917
EGFR downregulation pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_199123
Signaling by constitutively active EGFR pathway
REACT_254215
Signaling by GPCR pathway
REACT_198350
EGFR Transactivation by Gastrin pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_260286
SHC1 events in EGFR signaling pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_242456
Signaling by FGFR pathway
REACT_245103
GRB2 events in EGFR signaling pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa05223
Non-small cell lung cancer pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa05212
Pancreatic cancer pathway
hsa04020
Calcium signaling pathway pathway
hsa04320
Dorso-ventral axis formation pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
hsa05160
Hepatitis C pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu05213
Endometrial cancer pathway
mmu05219
Bladder cancer pathway
mmu04012
ErbB signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04540
Gap junction pathway
mmu05218
Melanoma pathway
mmu04912
GnRH signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu05214
Glioma pathway
mmu04520
Adherens junction pathway
mmu05215
Prostate cancer pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05212
Pancreatic cancer pathway
mmu04320
Dorso-ventral axis formation pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
lysophospholipid_pathway
LPA receptor mediated events
erbb1_internalization_pathway
Internalization of ErbB1
ptp1bpathway
Signaling events mediated by PTP1B
p53downstreampathway
Direct p53 effectors
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
erbb1_downstream_pathway
ErbB1 downstream signaling
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
syndecan_3_pathway
Syndecan-3-mediated signaling events
et_egfrpathway
EGFR-dependent Endothelin signaling events
tcptp_pathway
Signaling events mediated by TCPTP
erbb_network_pathway
ErbB receptor signaling network
shp2_pathway
SHP2 signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_pathway
Arf6 signaling events
telomerasepathway
Regulation of Telomerase
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL F1N7F3
UniProt Splice Variant
Entrez Gene 407217
UniGene Bt.6422
RefSeq XM_002696890 XM_592211
HUGO HGNC:3236
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02053434 DAAA02053435
GenPept
RNA Seq Atlas 407217

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca