Version 5.4
Bos taurus Gene: BT.36811
Summary
InnateDB Gene IDBG-644126.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.36811
Gene Name arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Synonyms DDEF1
Species Bos taurus
Ensembl Gene ENSBTAG00000003185
Encoded Proteins
IDBP-696751
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153317:
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:11327981-11696284
Strand Forward strand
Band
Transcripts
ENSBTAT00000048214 ENSBTAP00000045295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0060271 cilium morphogenesis
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000153317
View Gene Order
ENSMUSG00000022377
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04144
Endocytosis pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL E1B7Z1
UniProt Splice Variant
Entrez Gene 327705
UniGene Bt.36811
RefSeq NM_175821
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02037608 DAAA02037609 DAAA02037610 DAAA02037611 DAAA02037612 DAAA02037613 DAAA02037614 DAAA02037615 DAAA02037616 DAAA02037617
GenPept
RNA Seq Atlas 327705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca