Version 5.4
Homo sapiens Gene: ASAP1
Summary
InnateDB Gene IDBG-35667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASAP1
Gene Name ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000153317
Encoded Proteins
IDBP-35671
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-484960
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-478728
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-476504
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-482591
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-474672
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-479155
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-482233
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-482213
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
IDBP-480001
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:130052104-130443660
Strand Reverse strand
Band q24.22
Transcripts
ENST00000357668 ENSP00000350297
ENST00000524124 ENSP00000429391
ENST00000521075 ENSP00000428463
ENST00000518721 ENSP00000429900
ENST00000519483 ENSP00000429829
ENST00000520189
ENST00000521057
ENST00000524018
ENST00000524367 ENSP00000430588
ENST00000519169
ENST00000520342 ENSP00000428936
ENST00000520927 ENSP00000428629
ENST00000518957
ENST00000524299 ENSP00000429614
ENST00000521426 ENSP00000430917
ENST00000520625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022377
View Gene Order
ENSBTAG00000003185
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623560 Hs.655552 Hs.735932
RefSeq NM_001247996 NM_018482 XM_005250925 XM_006716563 XM_006716564 XM_006716565 XM_006716567
HUGO
OMIM
CCDS CCDS6362 CCDS75788
HPRD 05809
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca